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Brief History

Traditionally Ketamine has been used as a sedative and for anesthesia. Discovered in 1962, Ketamine was first used in humans in the mid-’60s. Since that time, it was mostly reserved for the use of emergency room physicians, anesthesiologists, and critical care physicians in the hospital setting. Most recently, Ketamine was found to have a profound beneficial effect on patients with chronic pain, depression, and PTSD. The advantage found with Ketamine is that it works immediately after the infusion is completed in about 70% to 80% of patients with a depressive state. With a different set of diagnoses to treat, Ketamine infusion clinics had become a reality, and outpatient infusion protocols were developed to help patients keep depression at bay.

Our Ketamine Protocol

At Indy Vital, we designed a program that uses intravenous Ketamine to revive, restore, revitalize, individuals who suffer from moderate to severe depression, PTSD, OCD, and Chronic Pain. Our goal is to bring you back to a healthy mental state using ketamine protocols that are safe and effective. Our providers, composed of a Board-Certified physician and an experienced nurse practitioner, are certified to prescribe and deliver Ketamine. Dr. Cris Vieira, our medical director, has performed over 3,000 procedures using conscious sedation. He also has extensive knowledge and experience in caring for patients who have a mental illness. Indy Vital has a safe, comfortable, and suitable ambiance to deliver intravenous Ketamine for a variety of diagnoses. Our providers use empathy, experience, and knowledge, helping people who suffer from depression at a spa-like atmosphere. Our state of the art facility provides us the ability to deliver the best care to our patients.

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Important Facts about Ketamine

- At Indy Vital, we utilize IV Ketamine to treat moderate to severe depression.
- Ketamine was recently approved, near-unanimously, by the FDA for the treatment of depression.
- In several studies, Ketamine helped debilitating mood disorders like severe depression with suicidal ideation, chronic pain, and obsessive-compulsive disorders.
- Ketamine is short-acting but promotes a lasting relief of depressive symptoms. After three to four infusions, about 70-80% of patients feel a great relief.
- It is not unusual for patients to experience three to six months of remission. We also offer a maintenance infusion that is given initially every two weeks and then once a month in trying to keep the symptoms of depression at bay.

How effective is Ketamine?

As a result of ketamine therapy, many patients experience improved productivity and see a decline in repeated cycles of abnormal behavior and thought processes. Multitasking and handling challenges may become more comfortable. With a clear mind, tasks that were difficult to complete may become much more relaxed, giving you a feeling of normalcy. 

What Should I Expect the day of my Ketamine Infusion?

The day you receive your infusion, you will need a driver to take you home. After receiving Ketamine, you are legally incapacitated to drive a vehicle for the remainder of the day. Before eery infusion, you will be asked to answer a questionnaire about how you feel to help us determine if the treatment is working along the course of 6 infusions. To be able to give you Ketamine, a small catheter will be inserted in a vein, usually in your hand, for venous access. After the IV catheter is secured, your IV Ketamine will start and usually lasts about 40-45 minutes. During the time you are receiving the treatment, we maintain continuous monitoring, watching your blood pressure, vital signs, and breathing that are recorded using a monitor. At Indy Vital, we value your privacy. We deliver Ketamine in a private treatment room for your comfort. During this process of treatment, we like you to feel at home. In trying to achieve just that, we create a calming atmosphere, dimming the lights and playing beautiful relaxing background music of your choice.

Ketamine Frequently Asked Questions

When was Ketamine first discovered?

Ketamine was discovered in 1962 and was first used as a sedative in humans in 1964.

How scientists found Ketamine works for depression?

Doctors working at the Veterans Hospital noticed that soldiers who suffered an injury during the war and received Ketamine during anesthesia had a much lower chance of developing PTSD and severe depression after they came home.

How effective is Ketamine for the treatment of depression?

Additional studies showed a great response to Ketamine with doctors reporting Ketamine infusions as a beacon of hope for veterans suffering from PTSD and major depressive disorder. Nearly 70%-80% of patients who have tried ketamine infusions have found immediate relief.

How does Ketamine work?

The exact mechanisms of how Ketamine works are currently unknown, but it seems that Ketamine works in the same area where anti-depressant medicines, the SSRIs work, just a lot faster. The theory is that Ketamine works by inhibition of the N-methyl-D-aspartate receptor. However, other mechanisms are possibly involved, including enhancement of descending inhibition and anti-inflammatory effects at central nervous sites.

How is Ketamine given to patients?

Ketamine is usually provided by infusion, meaning intravenous, using a butterfly needle or small an IV catheter, slowly in small doses over 45 minutes.

How does the doctor determine how many Ketamine infusions I need?

The doctor determines the number of infusions that one needs. It varies, but at Indy Vital, we recommend a minimum of 6 injections.

Is Ketamine FDA approved for the treatment of depression?

Ketamine has recently been approved nearly unanimously by the FDA as a medication for depression.

How many infusions are usually needed to see the long-lasting benefits of Ketamine?

Our protocol at INDY VITAL consists of six infusions, three times a week, for two weeks. A response is observed, and depending on the results, a maintenance dose every two weeks or months may be required to keep symptoms at bay.

Should I stop my anti-depressants if I use Ketamine?

We are not recommending that you stop your medicine or quit seeing your doctor or psychiatry. We like to work in conjunction with them in trying to help you recover faster and provide you with information that you could potentially improve your mood.

5252 E. 82nd Street, Suite 300
Indianapolis, IN 46250
Phone: 317-218-4308
Fax: 317-588-2647
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